Spirit Live

Spirit Group at ECCO 2019: Updates and Findings from the 14th Congress in Copenhagen

Last week, teams from Spirit Group travelled to the Bella Center in Copenhagen to attend the 14th Congress of ECCO. Delegates from across the globe came together at the biggest European congress for Inflammatory Bowel Disease to learn about the latest discoveries and updated therapies in the field of biomarkers, and how advancing technology (prominently,…Read more »

Last week, teams from Spirit Group travelled to the Bella Center in Copenhagen to attend the 14th Congress of ECCO.

Delegates from across the globe came together at the biggest European congress for Inflammatory Bowel Disease to learn about the latest discoveries and updated therapies in the field of biomarkers, and how advancing technology (prominently, artificial intelligence) will impact the entire medical community, from researchers to physicians to patients. With over 1,000 abstracts shared over the course of the congress, we have selected our top highlights from the week to share with you here.

Novel therapies

  • ABX464 demonstrated safety and efficacy in a proof-of-concept Phase IIa study in 32 patients with ulcerative colitis (presented by Jean-Marc Steens, OP21). ABX464 is a first-in-class small molecule that binds the cap binding complex, thereby enhancing splicing of an lncRNA, which ultimately leads to increased levels of miR-124, a potent anti-inflammatory microRNA
  • Mirikizumab, a p19-directed anti-IL-23 antibody, demonstrated safety and efficacy over the first 52 weeks of maintenance (presented by Geert D’Haens, OP38). Efficacy was similar in patients who had previous exposure to biologics, and in those who were biologic-naïve, and was observed with two dose regimens of mirikizumab
  • Can the old dog learn new tricks? A new subcutaneous formulation of infliximab showed similar efficacy and safety to the intravenous formulation and demonstrated consistent drug exposure during maintenance treatment (Walter Reinisch, DOP62). This may expand treatment options for infliximab, as maintaining specific trough levels of infliximab was shown to significantly increase remission rates in the PRECISION study (DOP56)

 

Updates on established therapies

  • The Phase IIIb study VARSITY demonstrated superior clinical remission and mucosal healing with vedolizumab compared with adalimumab in patients with ulcerative colitis; the clinical superiority of vedolizumab was most pronounced in the anti-TNF-naïve subpopulation (presented by Stefan Schreiber, OP34)
  • No new safety concerns were identified in the GEMINI long-term safety study of 9 years (presented by Remo Panaccione, OP26). The study included patients with Crohn’s disease or ulcerative colitis who received vedolizumab every 4 weeks
  • Updates on the UNIFI Phase III study showed that ustekinumab maintenance is safe and effective in patients with ulcerative colitis (presented by William Sandborn, OP37). In addition, further analyses in a subset of UNIFI patients showed that ustekinumab induction leads to suppression of inflammatory pathways and normalisation of colonic gene signature (OP13)
  • Updates on the OCTAVE studies (DOP41, DOP43) showed that tofacitinib is effective at inducing and maintaining remission and mucosal healing over 52 weeks regardless of prior anti-TNF exposure
  • A long-term follow-up of patients who completed the CALM study showed that remission at 1 year correlates with a decreased risk of disease complications over the next 3 years (presented by Clara Yzet, OP35). However, there was no statistically significant difference in long-term disease course between patients who were in the treat-to-target versus conventional management group

 

The era of Big Data

  • Hospital digital records grow by 48% each year. Every day the medical community invents new ways to use patient clinical records to gain a deeper understanding of disease predisposition and predict response to treatment. Some of the caveats may be defining data ownership, and if it belongs to patients rather than hospitals, and whether giving researchers access to such data will be complicated by the GDPR guidelines
  • A pilot study in Spain aims to integrate the clinical records of 3000 patients into a multidimensional model that will predict the course and outcomes of Crohn’s disease (PREMONITION-CD). Ignacio Hernandez-Medrano and colleagues are using computer linguistics to help transcribe free text medical records into specific data points that can subsequently be analysed by a machine. AI will not replace a physician, but we can harness its power to free physicians from many tasks and let them concentrate on interacting with patients
  • In the next couple of decades, we can expect to see a new wave of robotic surgery technology that will be more digitalised and integrated and will use machine learning to provide surgeons with actionable insights

 

What’s in a gut?

  • The results of a high-resolution genome–microbiome association study showed that the microbiome composition can be influenced by host genetics (presented by Shixian Hu, OP1)
  • Luc Biedermann (OP6) reported that the composition of mucosa-associated microbiota in patients in remission correlates with the host’s psychological wellbeing
  • Yet another study showed that individualised microbial variations in quiescent CD can precede and predict disease flare (DOP36)
  • Interestingly, both studies used machine learning to predict these associations; the study of Luc Biedermann and colleagues had 80–90% prediction accuracy
  • Is it possible that, in the future, therapeutic manipulation of microbiota may help improve patients’ quality of life and perhaps even prevent relapse?

 

Getting personal

  • As mentioned by Arthur Kaser, IBD is not one disease, but a spectrum of diseases that are affected by hundreds of candidate genetic mutations and an as yet unknown number of environmental factors. Currently available treatments are mostly generic suppressors of intestinal inflammation, but we are moving towards a future of personalised medicine
  • A number of candidate biomarkers are currently being explored. In order to utilise them effectively, the diagnostic and clinical classification systems need to be adjusted (for example, Montreal classification does not match the known molecular profiles of patient subpopulations). Further research is needed to integrate DNA/RNA and protein data with microbiome profiling
  • In the future, multi-omics-based analyses may help predict response to therapy and guide treatment decisions

 

A thought-provoking and thoroughly informative congress all round! If you have any questions or thoughts on any of the findings above, do not hesitate to contact our experienced team at Spirit Group here. We’re already looking forward to seeing what ECCO 2020 brings!

 

Share

TwitterFacebookLinkedInGoogle+Email

Spirit Group at the European Meeting of ISMPP, 22-23 January 2019

This year, over 300 publication professionals gathered at the European ISMPP meeting in London to discuss patient involvement, open access publishing, real-world evidence, data sharing, publication integrity, and many more engaging topics. We were very excited to see the growing interest in patients as active partners in clinical research and medical communications, relieved to witness…Read more »

This year, over 300 publication professionals gathered at the European ISMPP meeting in London to discuss patient involvement, open access publishing, real-world evidence, data sharing, publication integrity, and many more engaging topics. We were very excited to see the growing interest in patients as active partners in clinical research and medical communications, relieved to witness the increasing impact of real-world evidence, and braced ourselves for the exponential rise of the use of artificial intelligence in healthcare.

Enter your details here to request a copy of our Spotlight on ISMPP report, or contact us directly here to discuss any aspect of the evolution of the medical communications and the Spirit Group approach.

Share

TwitterFacebookLinkedInGoogle+Email

Spirit Group looking forward to attending ISMPP EU 2019

Spirit Group is getting ready to meet you at ISMPP (International Society for Medical Publication Professionals) Europe 2019. Come over and see us at stand 3 to discuss the latest trends in publication planning and how Spirit Group brings Personality to all of our communication programmes.

Spirit Group is getting ready to meet you at ISMPP (International Society for Medical Publication Professionals) Europe 2019. Come over and see us at stand 3 to discuss the latest trends in publication planning and how Spirit Group brings Personality to all of our communication programmes.

Share

TwitterFacebookLinkedInGoogle+Email

Santa visits Spirit Group

The Christmas festivities continue at Spirit Group! The Christmas tree went up in our Didsbury office on Monday morning, and now it really feels like the big day is only just around the corner! This year we are celebrating Christmas in new surroundings, as the Didsbury team relocated to our new office in Kingston House…Read more »

The Christmas festivities continue at Spirit Group!

The Christmas tree went up in our Didsbury office on Monday morning, and now it really feels like the big day is only just around the corner!

This year we are celebrating Christmas in new surroundings, as the Didsbury team relocated to our new office in Kingston House earlier this winter. Thanks to the continued success and growth of Spirit Group, we now have a much larger office to house our ever-expanding team…and a much larger space to decorate! And, as our Alderley Park team look forward to their office move in the new year, it looks like Christmas 2019 will be just as exciting….

Spirit’s Festive Day!

On 12th December, everyone at Spirit Group came together to celebrate our annual Festive Day. We marked the occasion with baileys, prosecco, mince pies and – of course – our best Christmas jumpers!

We enjoyed drinks and treats with lots of Christmas music, before swapping our Secret Santa gifts left under the Christmas tree. Santa even dropped in to say hello!

After business hours, some of our team headed into town to soak up the atmosphere at the Manchester Christmas Markets. It was impossible to feel anything other than festive cheer whilst surrounded by all the food, drink, gifts and great company!

 

We’ve had some wonderful fun over the last few weeks whilst we prepare for Christmas, and our Christmas party this week promises to round off the seasonal celebrations in style.

From all of us here at Spirit Group, we wish you a very merry Christmas and a happy New Year!

Share

TwitterFacebookLinkedInGoogle+Email

Spirit Group discusses Patient Engagement

Better informed patients = Better health outcomes – Spirit Group supports presentations on the gaps in information provision at PM Society Patient Engagement Interest Group event The PM Society’s Patient Engagement Interest Group (PEIG) hosted an insightful educational event at the Royal Society of Medicine in London on 27 November. The event gave the PEIG…Read more »

Better informed patients = Better health outcomes – Spirit Group supports presentations on the gaps in information provision at PM Society Patient Engagement Interest Group event

The PM Society’s Patient Engagement Interest Group (PEIG) hosted an insightful educational event at the Royal Society of Medicine in London on 27 November. The event gave the PEIG the opportunity to present the fascinating results of recent surveys of the views of doctors and patients alike.

Denise Silber, the Founder of Doctors 2.0 and You opened up proceedings on the day by reminding attendees that patient engagement is not a new concept.

Discussions about patient engagement started many years ago, with an initial focus on the important role of patient advocacy to represent the patients’ voice. Since then many more terms have been used, including e-patients, patient-centred care, patient engagement and participatory medicine. Many fantastic initiatives are now in place that really focus on patient involvement at all stages of their healthcare journey, but there is still a lot more to do, especially for more difficult to reach patient groups such as the young, the elderly and those with lower levels of literacy.

Assessing the health information needs of patients, caregivers, relatives and friends

One of Spirit Group’s Senior Scientific Directors, Nikki Kendrick, an active member of the PEIG, supported with a fully collaborative PEIG workstream survey that was circulated via the talkhealth platform and also distributed through the PEIG members’ own social media networks.

 

Spirit Group teams and their contacts also responded to the survey, providing their own personal insight on their information preferences either as carers or even patients themselves. Nikki co-presented the initial results of the survey (from 510 fully completed surveys) focusing on analysis of the quotes obtained through the open text fields. Overall, the online survey reported that those seeking health information did so on a regular (weekly/monthly) basis and most typically using technology, such as internet searching and mobile apps. Although as Deborah Wyatt pointed out in her presentation, this was an online survey! Despite being technically competent in using online sources, respondents still reported that they found many sources they searched out themselves either unhelpful or conflicting, adding to their confusion and causing frustration.

The information sources deemed most and least helpful amongst the survey respondents were:

The majority (43%) turned to online information sources because they felt they provided the most convenient and easy to access information. But they often doubted how trustworthy the information is and preferred getting information from their own doctor if that was possible. However, they were also aware of the time constraints in the health service system. Receiving direct communication with a personal touch was preferred by 22% of respondents.

Survey questions about the best types of information demonstrated clearly that no one type ticked all of the boxes for all people and so information should be provided in a variety of ways so that patients can have choice.

The survey also confirmed, amongst a smaller group of respondents who answered this section, that patient stories and local support, lay summaries of recent research and a system for access to experts on-demand would be very useful. The message seemed to be that even complex information was welcome and not to be avoided, although it should be presented in a clear, concise and straight forward language – just plain English!

In closing, both presenters confirmed how the results of the survey will really help in fine-tuning how all stakeholders, including the pharmaceutical industry, should approach the development of patient engagement strategies. The full results of the survey will be published in a PEIG White Paper after which the PEIG workstream will assess next steps e.g. the development of paper-based surveys, and other key areas that would warrant further investigation.

The event poster can be found on our twitter page here and the event summary from the PM Society can be found here.

Share

TwitterFacebookLinkedInGoogle+Email

Festive Spirit!

The countdown to Christmas begins! With advent beginning, our Operations team made themselves busy bringing the spirit of Christmas to our offices! Chocolate advent calendars appeared on Friday for our hard-working teams, ready for the Christmas countdown… Wreath making On Monday, creativity was fully flowing as Henry, Becky, Fiona, Caroline, Jess, Eve and Michelle created…Read more »

The countdown to Christmas begins!

With advent beginning, our Operations team made themselves busy bringing the spirit of Christmas to our offices! Chocolate advent calendars appeared on Friday for our hard-working teams, ready for the Christmas countdown…

Wreath making

On Monday, creativity was fully flowing as Henry, Becky, Fiona, Caroline, Jess, Eve and Michelle created some beautiful yuletide wreaths. A fun activity that also provided a chance to showcase Spirit Group’s artistic flair!

Christmas cheer

Clare, Henry and Lisa attended the Towers carol singing workshop led by the vocal leader and choral conductor of the Hallé orchestra, Michelle Robinson. Although billed as a performance by the Hallé singers, it turned out that it was the team who would be singing along!

Christmas shopping

Spirit Group also took some time out of the office to enjoy the Worker Bee Market stalls. Named after the Towers’ resident bees, the markets showcased Manchester-made artisan talent, with lots of decorations, handmade crafts, jewellery, food, gifts and treats.

Christmas feasting

To round off a great week, some of the team got together at Alderley Park to enjoy a huge Christmas lunch. It was so lovely to be surrounded by such great company…and great food!

What a fun, festive week for Spirit Group! But the Christmas celebrations are only just beginning for us…

Share

TwitterFacebookLinkedInGoogle+Email

Taking time out at Spirit Group

We have been getting involved in a range of volunteer work and activities to raise money for our amazing nominated charity, the Seashell Trust! Spirit Group teams have been taking time out of their busy work days to get down and dirty, doing much-needed ground works in the Seashell Trust gardens ahead of Autumn’s arrival….Read more »

We have been getting involved in a range of volunteer work and activities to raise money for our amazing nominated charity, the Seashell Trust!

Spirit Group teams have been taking time out of their busy work days to get down and dirty, doing much-needed ground works in the Seashell Trust gardens ahead of Autumn’s arrival.

The Spirit to ride

On Sunday 16th September, six members of Team Spirit Group donned their helmets and lycra for the Seashell Trust’s Cycling Sportive fundraiser event. Ed, Eve, Debbie, Laura, Lizzie and Steph bravely faced off the gruelling elements to cycle their chosen 50km or 75km routes through the hilly Peaks. Some of the pot holes they encountered put the Grand Canyon to shame!

A real test of endurance for our team and a brilliant outcome, with loads of money raised for the Seashell Trust to boot!

But the fundraising efforts haven’t stopped there for us – our office snack box exchanges donations for a selection of delicious and healthy nibbles, allowing us to collect money for the Seashell Trust every day. Even more tempting treats have appeared at both our Didsbury and Alderley Park offices in the form of a Bake Off, bringing in more donations!

 

We can’t wait for what the next few months hold as we continue to work together to raise all we can for the Seashell Trust!

Share

TwitterFacebookLinkedInGoogle+Email

The Spirit of giving back

Spirit Group is very pleased to announce that our nominated charity for 2018/19 will be the Seashell Trust, based in Cheadle Hulme, very near our Didsbury offices! Founded in 1873 as a school for deaf children, Seashell Trust now offers specialist programmes of care for children and young people with complex learning difficulties in their…Read more »

Spirit Group is very pleased to announce that our nominated charity for 2018/19 will be the Seashell Trust, based in Cheadle Hulme, very near our Didsbury offices!

Founded in 1873 as a school for deaf children, Seashell Trust now offers specialist programmes of care for children and young people with complex learning difficulties in their school, college and residential care homes.

Spirit Group teams from our Didsbury and Alderley Park offices will be getting stuck in at Seashell volunteer days and organising all kinds of activities to raise what we can for this wonderful cause. Some of the things we hope to get involved in are:

  • Administration
  • Befriending
  • Classroom support
  • Events
  • Gardening
  • Swimming and sport
  • Therapy

The funds we raise will go towards activity trips, assistive technology to help with communication and development, family events to support the parents and siblings of Seashell’s children and young people, and sports and therapy equipment.

We look forward to sharing our fund-raising and volunteering experiences that will all go towards improving the learning outcomes and quality of life of Seashell’s children and young people.

If you would like to learn more about Seashell and the work they do, please visit them at:

http://www.seashelltrust.org.uk/

https://www.facebook.com/Seashelltrust

https://twitter.com/seashelltrust

Share

TwitterFacebookLinkedInGoogle+Email

Game, set and match for Spirit Group!

Our Spirit Group summer business update provided a fantastic opportunity to bring together the majority of the Spirit Group family – our Didsbury and Alderley Park teams and our remote workers from across the UK. We celebrated a further quarter of medical communications success and growth, and our enthusiastic and forward-thinking Working Groups updated us…Read more »

Our Spirit Group summer business update provided a fantastic opportunity to bring together the majority of the Spirit Group family – our Didsbury and Alderley Park teams and our remote workers from across the UK. We celebrated a further quarter of medical communications success and growth, and our enthusiastic and forward-thinking Working Groups updated us on the business initiatives they have been prioritising to further enhance the executional and operational excellence that Spirit Group is renowned for.

The day was rounded off nicely with our own Wimbledon-themed event – complete with Pimms, strawberries & cream and lots of Spirited fun!

Share

TwitterFacebookLinkedInGoogle+Email

Spirit Group at EULAR 2018

This year’s European League Against Rheumatism (EULAR) congress was a busy one indeed! A record breaking >5000 abstract submissions and 32 industry-supported symposia, many running simultaneously, reflecting the highly-competitive nature of the meeting and underscoring the need for communications and content with a difference. Key front page EULAR Congress News themes included: Patient engagement with…Read more »

This year’s European League Against Rheumatism (EULAR) congress was a busy one indeed! A record breaking >5000 abstract submissions and 32 industry-supported symposia, many running simultaneously, reflecting the highly-competitive nature of the meeting and underscoring the need for communications and content with a difference.

Key front page EULAR Congress News themes included:

Patient engagement with their treatment and their disease
Enabling and encouraging patients to be more than passive participants in their own care was a very hot topic. Dr Yeliz Prior, PhD, Director of postgraduate research at the School of Health Sciences at the University of Salford in Manchester, UK noted that “We know that patient information and education have been shown to improve pain, self-efficacy and overall quality of life in people with musculoskeletal conditions (MSCs)”.  She added that “Informed patients are better equipped to distinguish and manage the symptoms of MSCs, use treatments effectively, identify and access [the] appropriate health and social care services they need, manage work and develop better coping strategies to deal with the negative psychological impact of their own conditions, such as stress, anxiety and depression”.

The ‘Don’t Delay, Connect Today’ campaign
The theme of patient engagement was also reflected in EULARs ‘Don’t Delay, Connect Today’ campaign. The campaign is now in its second year and aims to raise awareness of how important early diagnosis, and early treatment where indicated, is in preventing further damage for people with rheumatic and musculoskeletal diseases (RMDs). Prof. Gerd R. Burmester (Past President of EULAR and Professor of medicine at Berlin’s Charité University Clinic) noted that by encouraging people to work together, positive steps can be taken to improve the lives of those living with RMDs. This is particularly significant as awareness of the importance of early diagnosis is limited amongst the general public, in people with RMDs, and even among many doctors and health professionals in rheumatology.

Biosimilar use
The importance of keeping the patient at the centre of the decision to switch from an originator biologic to a biosimilar was also at the forefront of many presentations and discussions. There was a call for more randomised controlled trials on the safety of multiple switching, and discussion about the vital role of pharmacovigilance in confirming the safety of all biologics on a long-term basis.

We’re looking forward to next year’s agenda already!

Share

TwitterFacebookLinkedInGoogle+Email